What Is the Gut-Brain Axis?

Table of ContentsView AllTable of ContentsGut-Brain AxisThe Gut and Mental HealthWhat Can Harm Your Gut Health?Improving Gut Health

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Table of Contents

Gut-Brain Axis

The Gut and Mental Health

What Can Harm Your Gut Health?

Improving Gut Health

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The gut-brain axis is a system of two-way communication between the digestive system and central nervous system. Growing research suggests that the gut-brain axis, with a special focus on the health of the gut microbiome, can influence things like inflammation and disease, and even mental health.

Which Parts of the Body Make Up the Gut-Brain Axis?

When talking about the gut-brain axis, you might not realize all the parts of our body that are involved in this process of internal communication. There are three main areas of the body that are involved:

Digestive System

Our digestive system, specific to the gut-brain axis, is referring to the entire gastrointestinal tract. This means from your mouth, through the stomach and intestinal tract, to the anus. It is a complex system with unique features that help us to break down the food we eat to digest them properly, which can mean the absorbing of nutrients as well as helping us to eliminate waste.

Microbiome

The microbiome refers to the world of our gut health and the bacteria, both good and bad, that live in our gut. Our microbiome is made up of an estimated 39 trillion microbial cells including bacteria, viruses and fungi.

Brain

It may seem obvious that the brain would be a primary component of the gut brain axis. However, it is important to note thatneurotransmitters, chemicals that allow neurons to communicate with each other, are of particular importance when looking at the relationship between the gut and the brain.

Nervous System

The human nervous system can be considered the body’s command center. It is within the nervous system that communication throughout our body takes place, guiding our muscles and organs to function. The central nervous system and the enteric nervous system, which is part of theperipheral nervous system, are involved in the gut brain axis.

Central Nervous System

The central nervous system consists of the brain and the spinal cord. Information is carried through the body via electrical signals between neurons and responsible for receiving, processing and responding to sensory information.

Enteric Nervous System

The enteric nervous system is a large part of the peripheral nervous system and specific to our gastrointestinal system. Sometimes referred to as the gut brain or our second brain, the enteric nervous system is embedded in the gastrointestinal lining, starting in the lower part of the esophagus and ending at the anus. It directs movements of the gastrointestinal tract, regulates gastric acid secretion and gut hormone release, and interacts with the immune system in our gut.

The enteric nervous system is capable of functioning with or without input from the central nervous system.

Vagus Nerve

How the Gut-Brain Axis Influences Mental Health

Researchers are interested in studying the association of gut microbiota to gastrointestinal diseases. The inflammation of the gut has been linked to mental health disorders such as anxiety and depression.

Gut bacteria produce hundreds of neurochemicals that the brain uses to regulate physiological functions as well as mental processes such as learning, memory, and mood.

As the gut microbiome becomes inflamed or there is an imbalance between the good and bad gut bacteria, also known as dysbiosis, signals are sent to the brain that can cross the blood-brain barrier. This, in turn, can result in someone experiencing increased stress, anxiety, or depression, among other things.

It is suggested that a balanced gut microbiome, which means that there are adequate good bacteria present, can help regulate or stabilize mood and work to help decrease feelings of anxiety and depression.

Food

Much of what influences the health of our gut is our diet. There are many foods that can inhibit the growth of good bacteria and encourage the growth of bad bacteria. Some of the foods that can disrupt a healthy gut microbiome include foods such as:

Antibiotics

In addition to the foods we eat, another culprit in the disruption of a healthy gut is the use of antibiotics. Although antibiotics are sometimes necessary to help us fight illness and infections, these medicines often kill all gut bacteria, including the good bacteria we need for a healthy gut.

Lifestyle Factors

Lifestyle can play a significant role in our overall health, to include the health of our gut microbiome. Additional factors that can negatively impact the integrity and health of our gut include:

How to Improve Your Gut Health?

Just as there are common, everyday things that can impact our gut health in a negative way, there are some easy ways we can work to help improve the health of our gut microbiome. These include the foods we eat and avoid eating, limiting the use of antibiotics when possible, taking quality pre and probiotic supplements and managing our stress levels and other lifestyle factors.

Diet

Supplements

Prebiotics and probiotics are found in many of the foods listed above, some that you may already include in your diet. However, there are also pre and probiotic supplements that can be taken to help aid in the growth of a variety of good gut bacteria and help create a healthier gut microbiome. You can find many supplements over the counter at your local grocery store pharmacy or online.

Manage Stress

Lifestyle factors, particularly stress, can disrupt our gut health and influence the signals being communicated in the gut-brain axis. Having a plan to manage stress can be particularly helpful in addition to monitoring diet and taking probiotic supplements. Effective ways tomanage stresscan include things like:

As we engage in these activities, we are allowing our bodies to receive and process signals of physical and emotional safety. In addition, the more we can effectively manage stress, the less we will likely turn to other unhealthycoping skillssuch as poor food choices and smoking, for example.

3 SourcesVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Järbrink-Sehgal E, Andreasson A.The gut microbiota and mental health in adults. Curr Opin Neurobiol. 2020 Jun;62:102-114. doi:10.1016/j.conb.2020.01.016Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. doi:10.1155/2020/8024171Additional ReadingTerry N, Margolis KG.Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.Handb Exp Pharmacol. 2017;239:319-342. doi:10.1007/164_2016_103Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. https://doi.org/10.1155/2020/8024171

3 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Järbrink-Sehgal E, Andreasson A.The gut microbiota and mental health in adults. Curr Opin Neurobiol. 2020 Jun;62:102-114. doi:10.1016/j.conb.2020.01.016Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. doi:10.1155/2020/8024171Additional ReadingTerry N, Margolis KG.Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.Handb Exp Pharmacol. 2017;239:319-342. doi:10.1007/164_2016_103Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. https://doi.org/10.1155/2020/8024171

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Järbrink-Sehgal E, Andreasson A.The gut microbiota and mental health in adults. Curr Opin Neurobiol. 2020 Jun;62:102-114. doi:10.1016/j.conb.2020.01.016Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. doi:10.1155/2020/8024171

Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.

Järbrink-Sehgal E, Andreasson A.The gut microbiota and mental health in adults. Curr Opin Neurobiol. 2020 Jun;62:102-114. doi:10.1016/j.conb.2020.01.016

Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. doi:10.1155/2020/8024171

Terry N, Margolis KG.Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.Handb Exp Pharmacol. 2017;239:319-342. doi:10.1007/164_2016_103Appleton J.The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.Integr Med (Encinitas). 2018;17(4):28-32.Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. https://doi.org/10.1155/2020/8024171

Terry N, Margolis KG.Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.Handb Exp Pharmacol. 2017;239:319-342. doi:10.1007/164_2016_103

Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin, “The Enteric Nervous System and Its Emerging Role as a Therapeutic Target”,Gastroenterology Research and Practice, vol. 2020, Article ID 8024171, 13 pages, 2020. https://doi.org/10.1155/2020/8024171

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