Table of ContentsView AllTable of ContentsUsesCommon Side EffectsSerious Side EffectsResearchWarning and Precautions

Table of ContentsView All

View All

Table of Contents

Uses

Common Side Effects

Serious Side Effects

Research

Warning and Precautions

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Instead, t is now much more common to use a combination of Lamictal (lamotrigine) withlithiumif lamotrigine alone is not effective. If there is a need for further treatment, the addition of a second-generation medication, such as Vraylar, Latuda, or Rexulti, is often used.

Virtually all patients with this disorder experience the depressive phase, commonly referred to as bipolar depression. People with bipolar disorder typically have three times as many depressed days as they do manic days throughout their illness.

Common side effects that may go away with time include:

If any of these side effects don’t go away or cause problems, be sure to tell your doctor.

Potentially Serious Side Effects

If you have any of the following side effects, it’s important to contact your doctor right away as you may need medical treatment. These potentially serious side effects include:

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.For more mental health resources, see ourNational Helpline Database.988

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.For more mental health resources, see ourNational Helpline Database.

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see ourNational Helpline Database.

988

Other conditions that may occur after taking this condition include:

To minimize some of these risks, monitoring of fasting blood glucose and lipid profiles is recommended at the initiation and periodically throughout treatment.

Always tell your doctor about any medications, supplements, or substances you are currently taking to avoid potentially dangerous drug interactions. This includes other medications that may increase serotonin levels, which can lead to a dangerous condition called serotonin syndrome.

How to Recognize the Signs and Symptoms of Serotonin Syndrome

4 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Kupka RW, Altshuler LL, Nolen WA, et al.Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder.Bipolar Disord. 2007;9(5):531–535. doi:10.1111/j.1399-5618.2007.00467.x

Brunner E, Tohen M, Osuntokun O, Landry J, Thase ME.Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder.Neuropsychopharmacology. 2014;39(11):2549–2559. doi:10.1038/npp.2014.101

Silva MT, Zimmermann IR, Galvao TF, Pereira MG.Olanzapine plus fluoxetine for bipolar disorder: a systematic review and meta-analysis.J Affect Disord. 2013;146(3):310–318. doi:10.1016/j.jad.2012.11.001

Silva, M.T., Zimmermann, I.R., et. al. “Olanzapine plus fluoxetine for bipolar disorder: A systematic review and meta-analysis.“Journal of Affective Disorders146 (3), 2013.

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