Table of ContentsView AllTable of ContentsHow Reuptake WorksImportanceTypes of Reuptake MedicationsWarning for Serotonin Syndrome

Table of ContentsView All

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Table of Contents

How Reuptake Works

Importance

Types of Reuptake Medications

Warning for Serotonin Syndrome

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What is the most important information I should know about reuptake?Reuptake medications can have side effects.Some may lead to dependence and withdrawal symptoms when you stop taking them.These medications can interact with other drugs, including MAOIs and antipsychotics.

What is the most important information I should know about reuptake?

Reuptake medications can have side effects.Some may lead to dependence and withdrawal symptoms when you stop taking them.These medications can interact with other drugs, including MAOIs and antipsychotics.

Reuptakeis what happens after a signal is transmitted: The neurotransmitter, its “work” completed, is reabsorbed back into the cell that previously released it.

Reuptake is essential for synaptic functioning. It allows neurotransmitters to be reused and helps regulate neurotransmitter levels present in the synapse.

Why Is Reuptake Important in Treatment?

Increasing the amount of serotonin in the brain appears to help brain cells communicate, which in turn helps lift depression and improve mood. Serotonin has been called the body’s natural “feel-good” chemical because it produces a sense of well-being.

As you can see, SSRIs don’t help the body to produce more serotonin. Instead, they help the body circulate more of the serotonin it has.

There are a variety of reuptake medications available in addition to SSRIs. While these medications work in similar ways, they differ in terms of which neurotransmitters they target.Types of medications that affect reuptake include:

Examples of SSRIs

Here are the names of the SSRIs available for your doctor to prescribe:

What Are Selective Serotonin Reuptake Inhibitors (SSRIs)?

Types of SNRIs

SNRIs block transporters that are involved in the reuptake of serotonin and norepinephrine.Some common types of SNRIs include:

Types of NRIs

NRIs block the actions of the transporters involved in the reuptake of norepinephrine.Common NRIs include:

Types of SNDRIs

These triple reuptake inhibitors block the actions of transporters involved in the reuptake of serotonin, norepinephrine, and dopamine. These medications include:

Types of NDRIs

These medications block the transporters involved in the reuptake of norepinephrine and dopamine. Some of these medications include:

What to Know About Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs)

Theprocess of reuptakealso plays a role in this rare but dangerous condition, which generally occurs when a person takes more than one medication that increases the level of serotonin in the body. This can result in dangerously high serotonin levels in the brain.

Medications that should be taken with caution, if at all, with SSRIs include:Certain pain or headache medicationsThe herbal supplementSt. John’s WortCertain OTC cold and flu medications

Medications that should be taken with caution, if at all, with SSRIs include:

Signs and symptoms ofserotonin syndromeinclude:

If you have any of these signs or symptoms, get medical help immediately.

Serotonin syndrome is more likely to occur when you first start taking a serotonin-boosting medication or increase the dose.

Serotonin syndrome is rare, mainly because doctors are very careful about prescribing medications that could cause it. Nevertheless, because this syndrome is so dangerous, the FDA has asked the makers of these types of medications to put warning labels on them to alert you to this risk.

How to Recognize the Signs and Symptoms of Serotonin Syndrome

3 SourcesVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.American Psychological Association.Reuptake inhibitor.Sansone RA, Sansone LA.Serotonin norepinephrine reuptake inhibitors: A pharmacological comparison.Innov Clin Neurosci. 2014;11(3-4):37–42. PMID: 24800132Fasipe OJ.The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.IBRO Reports. 2019;6:95-110. doi:10.1016/j.ibror.2019.01.001

3 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.American Psychological Association.Reuptake inhibitor.Sansone RA, Sansone LA.Serotonin norepinephrine reuptake inhibitors: A pharmacological comparison.Innov Clin Neurosci. 2014;11(3-4):37–42. PMID: 24800132Fasipe OJ.The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.IBRO Reports. 2019;6:95-110. doi:10.1016/j.ibror.2019.01.001

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

American Psychological Association.Reuptake inhibitor.Sansone RA, Sansone LA.Serotonin norepinephrine reuptake inhibitors: A pharmacological comparison.Innov Clin Neurosci. 2014;11(3-4):37–42. PMID: 24800132Fasipe OJ.The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.IBRO Reports. 2019;6:95-110. doi:10.1016/j.ibror.2019.01.001

American Psychological Association.Reuptake inhibitor.

Sansone RA, Sansone LA.Serotonin norepinephrine reuptake inhibitors: A pharmacological comparison.Innov Clin Neurosci. 2014;11(3-4):37–42. PMID: 24800132

Fasipe OJ.The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents.IBRO Reports. 2019;6:95-110. doi:10.1016/j.ibror.2019.01.001

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