Table of ContentsView AllTable of ContentsAntidepressantsBenzodiazepinesAzapironesAntipsychotics/ AnticonvulsantsFinding the Right Medication

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Table of Contents

Antidepressants

Benzodiazepines

Azapirones

Antipsychotics/ Anticonvulsants

Finding the Right Medication

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What’s the most important thing to know about GAD medications?GAD medications have various potential side effects depending on the drug type, and they can range from mild to life-threatening.If you experience mild or bothersome side effects, such as fatigue or nausea, talk to your physician to discuss ways to relieve them.If you experience severe side effects, like irregular heartbeat or suicidal thoughts, seek immediate medical attention or call911.

What’s the most important thing to know about GAD medications?

GAD medications have various potential side effects depending on the drug type, and they can range from mild to life-threatening.If you experience mild or bothersome side effects, such as fatigue or nausea, talk to your physician to discuss ways to relieve them.If you experience severe side effects, like irregular heartbeat or suicidal thoughts, seek immediate medical attention or call911.

Generalized anxiety disorder medication options include:

While many types of medications can help manage GAD, each one varies in terms of side effects, addiction potential, and more. Understanding the benefits and risks of these drugs can help you decide which medications may be right for you.

Difference Between Normal Anxiety and GAD

Antidepressants for GAD

Even though the symptoms of anxiety and depression are not the same,antidepressant medicationsare often effective in managing anxiety.They’re considered first-line drugs for many anxiety disorders, or drugs that are a preferred treatment option.

Antidepressants can also be helpful for people with both GAD and depression. This is important since the two occur together frequently, with roughly one-half of people with GAD also havingmajor depressive disorder (MDD).

There are several differentclasses of antidepressantsthat can be used to reduce GAD symptoms, each one working in a slightly different way. Here are several to consider, along with their potential side effects and addiction risk.

Selective Serotonin Reuptake Inhibitors (SSRIs)

Selective serotonin reuptake inhibitors(SSRIs) are among the most preferred generalized anxiety disorder medications.This class of antidepressants includes medications such as Lexapro (escitalopram), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline).

Although SSRIs are generally well-tolerated, some people do experience side effects when taking them, with some of the most common adverse effects being:

SSRI side effects that are less common include extrapyramidal symptoms and serotonin syndrome.Extrapyramidal symptomsinclude muscle stiffness and involuntary muscle contractions. Increased anxiety, confusion, and irregular heartbeat are all signs of serotonin syndrome.

Serotonin syndrome can be life-threatening. If you experiencesigns of serotonin syndrome, it’s critical to get medical help immediately.

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

Whereas SSRIs block the reabsorption of serotonin,serotonin-norepinephrine reuptake inhibitors (SNRIs)block the reabsorption of both serotonin and norepinephrine. Norepinephrine is a neurotransmitter also involved with mood and sleep, along with memory, alertness, and arousal.

This class of antidepressants is another first-line anxiety medication and includes options such as Cymbalta (duloxetine) and Effexor (venlafaxine). Studies show that SSRIs are just as effective as SNRIs fortreating anxiety disorders.

Although side effects from SNRI medications generally improve as your body gets used to the drugs, some of the most common effects include:

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.For more mental health resources, see ourNational Helpline Database.

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911.

For more mental health resources, see ourNational Helpline Database.

How SSRIs and SNRIs are Different

Tricyclic Antidepressants (TCAs)

TCAs used to treat generalized anxiety disorder include Tofranil (imipramine), Pamelor (nortriptyline), and Anafranil (clomipramine). Generally speaking, these drugs are associated with more adverse effects than SSRIs or SNRIs; thus, other antidepressants should be tried first.

The most common side effects of TCAs, which often reduce over time, include:

TCAs may produce feelings similar to those of apanic attack.

One benefit of TCAs is that the risk of experiencingwithdrawal symptomswhen discontinuing these drugs is less than with many other antidepressants.If discontinuation effects do occur, then generally go away within one to two weeks.

Monoamine Oxidase Inhibitors (MAOIs)

MAOIs have been found to be effective in the treatment of several anxiety and depression disorders.There is, however, the potential for side effects when taking this category of medications.

Some side effects are minor, such as nausea, dizziness, dry mouth, and trouble sleeping. Others are more serious, including:

Benzodiazepines for Generalized Anxiety Disorder

Benzodiazepines have a high effective rate for GAD compared to other medication options.They’re also fast-acting, providing more immediate anxiety relief.Benzodiazepine medicationsinclude Klonopin (clonazepam), Ativan (lorazepam), and Xanax (alprazolam).

Benzodiazepines are generally well-tolerated but can have side effects such as:

One drawback of benzodiazepines is that, when used long-term, you can develop a dependence on or addiction to the drug. This can lead to withdrawal symptoms if it is discontinued, some of which include increased feelings of anxiety and the potential for seizures.Therefore, you never want to stop benzodiazepine use without the guidance of your healthcare provider.

If you or a loved one are struggling with substance use or addiction, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat1-800-662-4357for information on support and treatment facilities in your area.For more mental health resources, see ourNational Helpline Database.

If you or a loved one are struggling with substance use or addiction, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat1-800-662-4357for information on support and treatment facilities in your area.

Treating GAD With Azapirones

Since long-term use of benzodiazepines can lead to dependence and addiction, another type of generalized anxiety disorder medication with a better benefits-risk ratio over time is azapirones.Azapirones are drugs that have both anti-anxiety and antidepressant effects.

Buspirone is the only FDA-approved azapirone for treating GAD, and it has been found effective for this purpose.This drug was once available underthe brand name BuSpar, but that brand has since been discontinued. Now it is available under the generic name of buspirone.

Potential side effects associated with buspirone use include:

If you’ve used benzodiazepines in the past, you may find buspirone less effective, and you might also experience more side effects.

Unlike benzodiazepines, buspirone does not lead to drug dependence. When combined with an antidepressant, it can also help treat the adverse sexual side effects associated with the antidepressant drug.

Antipsychotic and Anticonvulsant GAD Medications

Other medications used for GAD include anticonvulsant (anti-seizure) medications and antipsychotics that fall into the category ofatypical antipsychotics. These treatments may be considered if you do not improve with traditional therapies or if you experience intolerable side effects from other GAD drugs.

The anticonvulsant drug pregabalin has been found to reduce anxiety quickly in people with GAD, along with having minimal side effects and a low abuse potential.That makes them another option to consider.

Atypical antipsychotics can be helpful as well, particularly for GAD that is treatment-resistant.Vortioxetine is an atypical antipsychotic GAD treatment option. Research has found that it is effective short term, along with being highly effective for people withsevere anxiety.

Finding the Right GAD Medication for You

Your mental health therapist can help you find the right general anxiety disorder medication for you. The important thing to remember is that you don’t have to live with anxiety. Many treatment options exist, including a variety of medication options.

Talk to your health provider about your GAD symptoms and treatment-related concerns. Based on your condition and situation, they can help find a medication that you feel comfortable taking.

If you or a loved one are struggling with anxiety, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat1-800-662-4357for information on support and treatment facilities in your area.For more mental health resources, see ourNational Helpline Database.

If you or a loved one are struggling with anxiety, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat1-800-662-4357for information on support and treatment facilities in your area.

23 SourcesVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Strawn JR. Geracioti L, Rajdev N, Clemena K, Levine A.Pharmacotherapy for generalized anxiety disorder in adults and pediatric patients: An evidence-based treatment review.Exp Opin Pharmacother. 2018;19(10):1057-1070. doi:10.1080/14656566.2018.1491966Bandelow B, Michaelis S, Wedekind D.Treatment of anxiety disorders.Dialog Clin Neurosci. 2017;19(2):93-107. doi:10.31887/DCNS.2017.19.2/bbandelowCoussement C, De Loungueville XD, Heeren A.Attentional networks in co-occurring generalized anxiety disorder and major depression disorder: Towards a staging approach to the executive control deficits.Comprehen Psychiatry. 2022;113:152294. doi:10.1016/j.comppsych.2021.152294Abejuela HR, Osser DN.The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An algorithm for generalized anxiety disorder.Harvard Rev Psychiatry. 2016;24(4):243-256. doi:10.1097/HRP.0000000000000098Cleveland Clinic.Serotonin.Albert PR, Vahid-Ansari F, Luckhart C.Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.Front Behav Neurosci. 2014;8:199. doi:10.3389/fnbeh.2014.00199Edinoff AN, Akuly HA, Hanna TA, et al.Selective serotonin reuptake inhibitors and adverse effects: A narrative review.Neurol Int. 2021;13(3):387-401. doi:10.3390/neurolint13030038Cleveland Clinic.Norepinephrine (noradrenaline).Jakubovski E, Johnson JA, Nasir M, Müller-Vahl K, Bloch MH.Systematic review and meta-analysis: Dose-response curve of SSRIs and SNRIs in anxiety disorders.Depress Anx. 2018;36(3):198-212. doi:10.1002/da.22854Cleveland Clinic.SNRIs (Serotonin and norepinephrine reuptake inhibitors).U.S. Food and Drug Administration.Suicidality in children and adolescents being treated with antidepressant medications.Cleveland Clinic.Beyond depression: Other uses for tricyclic antidepressants.Menkes D, Bosanac P, Castle D.MAOIs — does the evidence warrant their resurrection?Australas Psychiatry. 2016;24(4):271-3. doi:10.1177/1039856216634824American Academy of Private Physicians.Monoamine oxidase inhibitors (MAOI): Potential adverse effects: Monitoring, prevention and management.Anxiety & Depression Association of America.SSRIs and benzodiazepines for general anxiety disorders (GAD).Gomez AF, Barthel AL, Hofmann SG.Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review.Exp Opin Pharmacother. 2018;19(8):883-894. doi:10.1080/14656566.2018.1472767Soyka M.Treatment of benzodiazepine dependence.New Eng J Med. 2017;376:1147-1157. doi:10.1056/NEJMra1611832Knap B, Kwiatkowski S, Kolasińska K, et al.Azapirones for the treatment of anxiety — an overview.World Sci News. 2018;109:14-25.Garakani A, Murrough JW, Freire RF, et al.Pharmacotherapy of anxiety disorders: current and emerging treatment options.Front Psychiatry. 2020;11:595584. doi:10.3389/fpsyt.2020.595584Howland R.Buspirone: Back to the future.J Psychosoc Nurs Mental Health Serv. 2015;53(11):21-24. doi:10.3928/02793695-20151-22-01Zahreddine N, Richa S.Non-antidepressant treatment of generalized anxiety disorder.Curr Clin Pharmacol. 2015;10(2):86-96. doi:10.2174/15748847113089990058Ansara ED.Management of treatment-resistant generalized anxiety disorder.Ment Health Clinic. 2020;10(6):326-334. doi:10.9740/mhc.2020.11.326Pae C, Wang S, Han C, et al.Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: A systematic review and meta-analysis.J Psychiatric Res. 2015;64:88-98. doi:10.1016/j.jpsychires.2015.02.017Additional ReadingMelarango AJ.Pharmacology for anxiety disorders: From first-line options to treatment resistance.Focus. 2021;19(2):145-160. doi:10.1176/appi.focus.20200048

23 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Strawn JR. Geracioti L, Rajdev N, Clemena K, Levine A.Pharmacotherapy for generalized anxiety disorder in adults and pediatric patients: An evidence-based treatment review.Exp Opin Pharmacother. 2018;19(10):1057-1070. doi:10.1080/14656566.2018.1491966Bandelow B, Michaelis S, Wedekind D.Treatment of anxiety disorders.Dialog Clin Neurosci. 2017;19(2):93-107. doi:10.31887/DCNS.2017.19.2/bbandelowCoussement C, De Loungueville XD, Heeren A.Attentional networks in co-occurring generalized anxiety disorder and major depression disorder: Towards a staging approach to the executive control deficits.Comprehen Psychiatry. 2022;113:152294. doi:10.1016/j.comppsych.2021.152294Abejuela HR, Osser DN.The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An algorithm for generalized anxiety disorder.Harvard Rev Psychiatry. 2016;24(4):243-256. doi:10.1097/HRP.0000000000000098Cleveland Clinic.Serotonin.Albert PR, Vahid-Ansari F, Luckhart C.Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.Front Behav Neurosci. 2014;8:199. doi:10.3389/fnbeh.2014.00199Edinoff AN, Akuly HA, Hanna TA, et al.Selective serotonin reuptake inhibitors and adverse effects: A narrative review.Neurol Int. 2021;13(3):387-401. doi:10.3390/neurolint13030038Cleveland Clinic.Norepinephrine (noradrenaline).Jakubovski E, Johnson JA, Nasir M, Müller-Vahl K, Bloch MH.Systematic review and meta-analysis: Dose-response curve of SSRIs and SNRIs in anxiety disorders.Depress Anx. 2018;36(3):198-212. doi:10.1002/da.22854Cleveland Clinic.SNRIs (Serotonin and norepinephrine reuptake inhibitors).U.S. Food and Drug Administration.Suicidality in children and adolescents being treated with antidepressant medications.Cleveland Clinic.Beyond depression: Other uses for tricyclic antidepressants.Menkes D, Bosanac P, Castle D.MAOIs — does the evidence warrant their resurrection?Australas Psychiatry. 2016;24(4):271-3. doi:10.1177/1039856216634824American Academy of Private Physicians.Monoamine oxidase inhibitors (MAOI): Potential adverse effects: Monitoring, prevention and management.Anxiety & Depression Association of America.SSRIs and benzodiazepines for general anxiety disorders (GAD).Gomez AF, Barthel AL, Hofmann SG.Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review.Exp Opin Pharmacother. 2018;19(8):883-894. doi:10.1080/14656566.2018.1472767Soyka M.Treatment of benzodiazepine dependence.New Eng J Med. 2017;376:1147-1157. doi:10.1056/NEJMra1611832Knap B, Kwiatkowski S, Kolasińska K, et al.Azapirones for the treatment of anxiety — an overview.World Sci News. 2018;109:14-25.Garakani A, Murrough JW, Freire RF, et al.Pharmacotherapy of anxiety disorders: current and emerging treatment options.Front Psychiatry. 2020;11:595584. doi:10.3389/fpsyt.2020.595584Howland R.Buspirone: Back to the future.J Psychosoc Nurs Mental Health Serv. 2015;53(11):21-24. doi:10.3928/02793695-20151-22-01Zahreddine N, Richa S.Non-antidepressant treatment of generalized anxiety disorder.Curr Clin Pharmacol. 2015;10(2):86-96. doi:10.2174/15748847113089990058Ansara ED.Management of treatment-resistant generalized anxiety disorder.Ment Health Clinic. 2020;10(6):326-334. doi:10.9740/mhc.2020.11.326Pae C, Wang S, Han C, et al.Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: A systematic review and meta-analysis.J Psychiatric Res. 2015;64:88-98. doi:10.1016/j.jpsychires.2015.02.017Additional ReadingMelarango AJ.Pharmacology for anxiety disorders: From first-line options to treatment resistance.Focus. 2021;19(2):145-160. doi:10.1176/appi.focus.20200048

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Strawn JR. Geracioti L, Rajdev N, Clemena K, Levine A.Pharmacotherapy for generalized anxiety disorder in adults and pediatric patients: An evidence-based treatment review.Exp Opin Pharmacother. 2018;19(10):1057-1070. doi:10.1080/14656566.2018.1491966Bandelow B, Michaelis S, Wedekind D.Treatment of anxiety disorders.Dialog Clin Neurosci. 2017;19(2):93-107. doi:10.31887/DCNS.2017.19.2/bbandelowCoussement C, De Loungueville XD, Heeren A.Attentional networks in co-occurring generalized anxiety disorder and major depression disorder: Towards a staging approach to the executive control deficits.Comprehen Psychiatry. 2022;113:152294. doi:10.1016/j.comppsych.2021.152294Abejuela HR, Osser DN.The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An algorithm for generalized anxiety disorder.Harvard Rev Psychiatry. 2016;24(4):243-256. doi:10.1097/HRP.0000000000000098Cleveland Clinic.Serotonin.Albert PR, Vahid-Ansari F, Luckhart C.Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.Front Behav Neurosci. 2014;8:199. doi:10.3389/fnbeh.2014.00199Edinoff AN, Akuly HA, Hanna TA, et al.Selective serotonin reuptake inhibitors and adverse effects: A narrative review.Neurol Int. 2021;13(3):387-401. doi:10.3390/neurolint13030038Cleveland Clinic.Norepinephrine (noradrenaline).Jakubovski E, Johnson JA, Nasir M, Müller-Vahl K, Bloch MH.Systematic review and meta-analysis: Dose-response curve of SSRIs and SNRIs in anxiety disorders.Depress Anx. 2018;36(3):198-212. doi:10.1002/da.22854Cleveland Clinic.SNRIs (Serotonin and norepinephrine reuptake inhibitors).U.S. Food and Drug Administration.Suicidality in children and adolescents being treated with antidepressant medications.Cleveland Clinic.Beyond depression: Other uses for tricyclic antidepressants.Menkes D, Bosanac P, Castle D.MAOIs — does the evidence warrant their resurrection?Australas Psychiatry. 2016;24(4):271-3. doi:10.1177/1039856216634824American Academy of Private Physicians.Monoamine oxidase inhibitors (MAOI): Potential adverse effects: Monitoring, prevention and management.Anxiety & Depression Association of America.SSRIs and benzodiazepines for general anxiety disorders (GAD).Gomez AF, Barthel AL, Hofmann SG.Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review.Exp Opin Pharmacother. 2018;19(8):883-894. doi:10.1080/14656566.2018.1472767Soyka M.Treatment of benzodiazepine dependence.New Eng J Med. 2017;376:1147-1157. doi:10.1056/NEJMra1611832Knap B, Kwiatkowski S, Kolasińska K, et al.Azapirones for the treatment of anxiety — an overview.World Sci News. 2018;109:14-25.Garakani A, Murrough JW, Freire RF, et al.Pharmacotherapy of anxiety disorders: current and emerging treatment options.Front Psychiatry. 2020;11:595584. doi:10.3389/fpsyt.2020.595584Howland R.Buspirone: Back to the future.J Psychosoc Nurs Mental Health Serv. 2015;53(11):21-24. doi:10.3928/02793695-20151-22-01Zahreddine N, Richa S.Non-antidepressant treatment of generalized anxiety disorder.Curr Clin Pharmacol. 2015;10(2):86-96. doi:10.2174/15748847113089990058Ansara ED.Management of treatment-resistant generalized anxiety disorder.Ment Health Clinic. 2020;10(6):326-334. doi:10.9740/mhc.2020.11.326Pae C, Wang S, Han C, et al.Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: A systematic review and meta-analysis.J Psychiatric Res. 2015;64:88-98. doi:10.1016/j.jpsychires.2015.02.017

Strawn JR. Geracioti L, Rajdev N, Clemena K, Levine A.Pharmacotherapy for generalized anxiety disorder in adults and pediatric patients: An evidence-based treatment review.Exp Opin Pharmacother. 2018;19(10):1057-1070. doi:10.1080/14656566.2018.1491966

Bandelow B, Michaelis S, Wedekind D.Treatment of anxiety disorders.Dialog Clin Neurosci. 2017;19(2):93-107. doi:10.31887/DCNS.2017.19.2/bbandelow

Coussement C, De Loungueville XD, Heeren A.Attentional networks in co-occurring generalized anxiety disorder and major depression disorder: Towards a staging approach to the executive control deficits.Comprehen Psychiatry. 2022;113:152294. doi:10.1016/j.comppsych.2021.152294

Abejuela HR, Osser DN.The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An algorithm for generalized anxiety disorder.Harvard Rev Psychiatry. 2016;24(4):243-256. doi:10.1097/HRP.0000000000000098

Cleveland Clinic.Serotonin.

Albert PR, Vahid-Ansari F, Luckhart C.Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.Front Behav Neurosci. 2014;8:199. doi:10.3389/fnbeh.2014.00199

Edinoff AN, Akuly HA, Hanna TA, et al.Selective serotonin reuptake inhibitors and adverse effects: A narrative review.Neurol Int. 2021;13(3):387-401. doi:10.3390/neurolint13030038

Cleveland Clinic.Norepinephrine (noradrenaline).

Jakubovski E, Johnson JA, Nasir M, Müller-Vahl K, Bloch MH.Systematic review and meta-analysis: Dose-response curve of SSRIs and SNRIs in anxiety disorders.Depress Anx. 2018;36(3):198-212. doi:10.1002/da.22854

Cleveland Clinic.SNRIs (Serotonin and norepinephrine reuptake inhibitors).

U.S. Food and Drug Administration.Suicidality in children and adolescents being treated with antidepressant medications.

Cleveland Clinic.Beyond depression: Other uses for tricyclic antidepressants.

Menkes D, Bosanac P, Castle D.MAOIs — does the evidence warrant their resurrection?Australas Psychiatry. 2016;24(4):271-3. doi:10.1177/1039856216634824

American Academy of Private Physicians.Monoamine oxidase inhibitors (MAOI): Potential adverse effects: Monitoring, prevention and management.

Anxiety & Depression Association of America.SSRIs and benzodiazepines for general anxiety disorders (GAD).

Gomez AF, Barthel AL, Hofmann SG.Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review.Exp Opin Pharmacother. 2018;19(8):883-894. doi:10.1080/14656566.2018.1472767

Soyka M.Treatment of benzodiazepine dependence.New Eng J Med. 2017;376:1147-1157. doi:10.1056/NEJMra1611832

Knap B, Kwiatkowski S, Kolasińska K, et al.Azapirones for the treatment of anxiety — an overview.World Sci News. 2018;109:14-25.

Garakani A, Murrough JW, Freire RF, et al.Pharmacotherapy of anxiety disorders: current and emerging treatment options.Front Psychiatry. 2020;11:595584. doi:10.3389/fpsyt.2020.595584

Howland R.Buspirone: Back to the future.J Psychosoc Nurs Mental Health Serv. 2015;53(11):21-24. doi:10.3928/02793695-20151-22-01

Zahreddine N, Richa S.Non-antidepressant treatment of generalized anxiety disorder.Curr Clin Pharmacol. 2015;10(2):86-96. doi:10.2174/15748847113089990058

Ansara ED.Management of treatment-resistant generalized anxiety disorder.Ment Health Clinic. 2020;10(6):326-334. doi:10.9740/mhc.2020.11.326

Pae C, Wang S, Han C, et al.Vortioxetine, a multimodal antidepressant for generalized anxiety disorder: A systematic review and meta-analysis.J Psychiatric Res. 2015;64:88-98. doi:10.1016/j.jpsychires.2015.02.017

Melarango AJ.Pharmacology for anxiety disorders: From first-line options to treatment resistance.Focus. 2021;19(2):145-160. doi:10.1176/appi.focus.20200048

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