Table of ContentsView AllTable of ContentsHow Latuda WorksWarningsSide EffectsPrecautions

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Table of Contents

How Latuda Works

Warnings

Side Effects

Precautions

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What is the most important information I should know about Latuda?You should not take Latuda if you:have a known hypersensitivity to lurasidone or any other ingredients in Latuda; orare taking a strong CYP3A4 inhibitor such as ketoconazole or an inducer such as rifampin; orare an older adult with dementia-related psychosis.

What is the most important information I should know about Latuda?

You should not take Latuda if you:have a known hypersensitivity to lurasidone or any other ingredients in Latuda; orare taking a strong CYP3A4 inhibitor such as ketoconazole or an inducer such as rifampin; orare an older adult with dementia-related psychosis.

You should not take Latuda if you:

Latuda (lurasidone) is one of the second-generation antipsychotic medications that are referred to asatypical antipsychotics. Latuda was first approved for the treatment ofschizophreniain 2010. The Food and Drug Administration then approved its use to help in the treatment of bipolar depression in 2013.

Like other psychotropic medicines, Latuda can cause side effects and carries warnings that you should be aware of before you take it. Here’s what you should know before you take Latuda for schizophrenia or bipolar disorder, including the potential side effects you might experience, warnings, and important precautions.

It can also help improve symptoms of schizophrenia, including:

Off-Label UsesLatuda may also sometimes be prescribed off-label in the treatment of other conditions such as depression,bipolar II disorder,obsessive-compulsive disorder (OCD), anxiety, and insomnia.

Off-Label Uses

Latuda may also sometimes be prescribed off-label in the treatment of other conditions such as depression,bipolar II disorder,obsessive-compulsive disorder (OCD), anxiety, and insomnia.

Warnings for Latuda

Like all antipsychotic drugs, Latuda carries a boxed warning saying it is not approved for use in elderly patients with dementia-related psychosis due to increased risk of death.

There is the potential for developing neuroleptic malignant syndrome (NMS) when taking all antipsychotics, including Latuda. Symptoms can include abnormally high fever, rigid muscles, profuse sweating, irregular heartbeat, and other symptoms. Kidney failure can result.

Although rare, this is an extremely serious and potentially fatal condition, so it is important to recognize the symptoms and seek treatment at once.

Althoughtardive dyskinesia(TD) is rarer among patients taking the atypicalantipsychoticscompared to the oldertypicalagents, TD may still rarely develop in patients taking Latuda.The most common presentation of tardive dyskinesia is forms of uncontrolled facial movements. Again, know the symptoms of this condition and contact your doctor at once if they appear.

There are additional warnings common to all antipsychotics about less serious possible side effects. Read all the literature accompanying your prescription carefully and discuss any concerns you may have with your doctor.

The Food and Drug Administration (FDA) issued ablack box warning on all antipsychotic drugs, including Latuda, due to the increased risk of death in older adults (those 65 and older) when used to treat symptoms of dementia.

Other Latuda Warnings

All antipsychotic medications also carry warnings about the possibility of weight gain, increased blood sugar, cholesterol and triglycerides, with the potential to lead to diabetes.However, the clinical trials and studies so far have indicated that Latuda’s effect on weight is more complex.

Some research has found that people taking Latuda lose weight while taking it. Overall, it is currently considered not to be associated with weight gain.

Common Side Effects of Latuda

The most common side effects in clinical trials were:

The latter two are movement disorders that can be serious and/or extremely distressing. Be aware of the symptoms of these conditions and alert your doctor if you begin to experience them.

Dystonia, parkinsonism, and akathisia are referred to asextrapyramidal side effects. These symptoms can occur when taking antipsychotic medications, although these are less common when taking atypical antipsychotics.

Precautions Before Taking Latuda

Before taking Latuda, talk to your doctor about any medications, supplements, or substances you currently take. This is important to avoid any potential drug interactions.

You should also inform your doctor if you have a history of heart rhythm problems, heart attacks, long QT syndrome, high cholesterol, seizures, or diabetes.

Use in Pregnancy

There have been no adequate or well-controlled studies of Latuda during pregnancy. At this time, the recommendation is that the drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

If you become pregnant while taking Latuda, make sure to discuss this with your physician.

8 SourcesVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.National Alliance on Mental Illness.Luradisone (Latuda).Suppes T, Silva R, Cucchiaro J, et al.Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study.AJP. 2016;173(4):400-407. doi:10.1176/appi.ajp.2015.15060770Lindström L, Lindström E, Nilsson M, Höistad M.Maintenance therapy with second generation antipsychotics for bipolar disorder – A systematic review and meta-analysis.Journal of Affective Disorders. 2017;213:138-150. doi:10.1016/j.jad.2017.02.012Krystal AD, Zammit G.The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.Hum Psychopharmacol. 2016;31(3):206-216. doi:10.1002/hup.2533U.S. Food and Drug Administration.Latuda (lurasidone HCI) tablets: Highlights of prescribing information.Maust DT, Kim HM, Seyfried LS, et al.Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.JAMA Psychiatry. 2015;72(5):438-445. doi:10.1001/jamapsychiatry.2014.3018Meyer JM, Ng-Mak DS, Chuang CC, Rajagopalan K, Loebel A.Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records.Ann Gen Psychiatry. 2017;16:36. doi:10.1186/s12991-017-0159-xAbu-Naser D, Gharaibeh S, Al Meslamani AZ, Alefan Q, Abunaser R.Assessment of extrapyramidal symptoms associated with psychotropics pharmacological treatments, and associated risk factors.Clin Pract Epidemiol Ment Health. 2021;17:1-7. doi:10.2174/1745017902117010001

8 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.National Alliance on Mental Illness.Luradisone (Latuda).Suppes T, Silva R, Cucchiaro J, et al.Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study.AJP. 2016;173(4):400-407. doi:10.1176/appi.ajp.2015.15060770Lindström L, Lindström E, Nilsson M, Höistad M.Maintenance therapy with second generation antipsychotics for bipolar disorder – A systematic review and meta-analysis.Journal of Affective Disorders. 2017;213:138-150. doi:10.1016/j.jad.2017.02.012Krystal AD, Zammit G.The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.Hum Psychopharmacol. 2016;31(3):206-216. doi:10.1002/hup.2533U.S. Food and Drug Administration.Latuda (lurasidone HCI) tablets: Highlights of prescribing information.Maust DT, Kim HM, Seyfried LS, et al.Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.JAMA Psychiatry. 2015;72(5):438-445. doi:10.1001/jamapsychiatry.2014.3018Meyer JM, Ng-Mak DS, Chuang CC, Rajagopalan K, Loebel A.Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records.Ann Gen Psychiatry. 2017;16:36. doi:10.1186/s12991-017-0159-xAbu-Naser D, Gharaibeh S, Al Meslamani AZ, Alefan Q, Abunaser R.Assessment of extrapyramidal symptoms associated with psychotropics pharmacological treatments, and associated risk factors.Clin Pract Epidemiol Ment Health. 2021;17:1-7. doi:10.2174/1745017902117010001

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

National Alliance on Mental Illness.Luradisone (Latuda).Suppes T, Silva R, Cucchiaro J, et al.Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study.AJP. 2016;173(4):400-407. doi:10.1176/appi.ajp.2015.15060770Lindström L, Lindström E, Nilsson M, Höistad M.Maintenance therapy with second generation antipsychotics for bipolar disorder – A systematic review and meta-analysis.Journal of Affective Disorders. 2017;213:138-150. doi:10.1016/j.jad.2017.02.012Krystal AD, Zammit G.The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.Hum Psychopharmacol. 2016;31(3):206-216. doi:10.1002/hup.2533U.S. Food and Drug Administration.Latuda (lurasidone HCI) tablets: Highlights of prescribing information.Maust DT, Kim HM, Seyfried LS, et al.Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.JAMA Psychiatry. 2015;72(5):438-445. doi:10.1001/jamapsychiatry.2014.3018Meyer JM, Ng-Mak DS, Chuang CC, Rajagopalan K, Loebel A.Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records.Ann Gen Psychiatry. 2017;16:36. doi:10.1186/s12991-017-0159-xAbu-Naser D, Gharaibeh S, Al Meslamani AZ, Alefan Q, Abunaser R.Assessment of extrapyramidal symptoms associated with psychotropics pharmacological treatments, and associated risk factors.Clin Pract Epidemiol Ment Health. 2021;17:1-7. doi:10.2174/1745017902117010001

National Alliance on Mental Illness.Luradisone (Latuda).

Suppes T, Silva R, Cucchiaro J, et al.Lurasidone for the treatment of major depressive disorder with mixed features: a randomized, double-blind, placebo-controlled study.AJP. 2016;173(4):400-407. doi:10.1176/appi.ajp.2015.15060770

Lindström L, Lindström E, Nilsson M, Höistad M.Maintenance therapy with second generation antipsychotics for bipolar disorder – A systematic review and meta-analysis.Journal of Affective Disorders. 2017;213:138-150. doi:10.1016/j.jad.2017.02.012

Krystal AD, Zammit G.The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia.Hum Psychopharmacol. 2016;31(3):206-216. doi:10.1002/hup.2533

U.S. Food and Drug Administration.Latuda (lurasidone HCI) tablets: Highlights of prescribing information.

Maust DT, Kim HM, Seyfried LS, et al.Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm.JAMA Psychiatry. 2015;72(5):438-445. doi:10.1001/jamapsychiatry.2014.3018

Meyer JM, Ng-Mak DS, Chuang CC, Rajagopalan K, Loebel A.Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records.Ann Gen Psychiatry. 2017;16:36. doi:10.1186/s12991-017-0159-x

Abu-Naser D, Gharaibeh S, Al Meslamani AZ, Alefan Q, Abunaser R.Assessment of extrapyramidal symptoms associated with psychotropics pharmacological treatments, and associated risk factors.Clin Pract Epidemiol Ment Health. 2021;17:1-7. doi:10.2174/1745017902117010001

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