Table of ContentsView AllTable of ContentsPotential Health BenefitsUsesPossible Side EffectsDosage and PreparationWhat to Look ForFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
Potential Health Benefits
Uses
Possible Side Effects
Dosage and Preparation
What to Look For
Frequently Asked Questions
Close
What is the most important information I should know about inositol?While inositol has been investigated for potential mental health benefits, there is not enough evidence to support its use as a treatment for conditions such as anxiety, depression, or bipolar disorder.Inositol supplements may cause side effects. Common side effects include stomach pain, headache, dizziness, and low blood sugar.Talk to your doctor before taking these supplements, and tell them about any other medications you are currently taking.
What is the most important information I should know about inositol?
While inositol has been investigated for potential mental health benefits, there is not enough evidence to support its use as a treatment for conditions such as anxiety, depression, or bipolar disorder.Inositol supplements may cause side effects. Common side effects include stomach pain, headache, dizziness, and low blood sugar.Talk to your doctor before taking these supplements, and tell them about any other medications you are currently taking.
Inositol is a type of sugar that influences both the body’s insulin response and several hormones associated withmoodand cognition. It’s often referred to asvitamin B8, but it is not actually a vitamin.
Inositol is found naturally in cantaloupe, citrus fruit, and many fiber-rich foods (such as beans, brown rice, corn, sesame seeds, and wheat bran). It is also sold in supplement form and used as a complementary therapy to treat a wide range of medical conditions, including metabolic andmood disorders.
D-chiro-inositol, inositol hexaphosphate (often referred to as “IP6”), and the compound myo-inositol are the most widely used inositol supplements. They are generally considered safe if taken appropriately.
Keep reading to learn more about the potential mental health benefits and uses of inositol. Also, learn more about the dosage, preparation, possible side effects, and interactions you should consider before taking this substance.
Commonly Known AsInositolD-chiro-inositolInositol hexaphosphate (or “IP6”)Myo-inositol
Commonly Known As
InositolD-chiro-inositolInositol hexaphosphate (or “IP6”)Myo-inositol
Verywell / Cindy Chung
Potential Mental Health Benefits of Inositol
Inositol plays an important part in cell growth and functioning.Some research has found that inositol may have a number of health benefits, including relieving symptoms ofdepression.Some research also indicates that inositol might help relieveanxietyand symptoms ofpanic disorder.
It is important to note, however, that much of this research is preliminary and results are sometimes mixed. For example, one study concluded that while inositol showed some promise for panic disorder, the evidence does not support the use of inositol as a treatment.
Other Potential Health BenefitsLowering the risk of metabolic syndrome, which is a risk factor for a number of conditions, including increased belly fat, high blood pressure, and high blood sugarLoweringhigh cholesterolHelping the body regulate and process insulinReducing the risk of gestational diabetesRelieving symptoms ofpolycystic ovary syndrome (PCOS)
Other Potential Health Benefits
Lowering the risk of metabolic syndrome, which is a risk factor for a number of conditions, including increased belly fat, high blood pressure, and high blood sugarLoweringhigh cholesterolHelping the body regulate and process insulinReducing the risk of gestational diabetesRelieving symptoms ofpolycystic ovary syndrome (PCOS)
Mental Health Uses for Inositol
What is inositol used for? Alternative health providers recommend inositol supplements for a wide range of health conditions, including mood disorders, anxiety,ADHD, andPTSD. There is some research that inositol may benefit some disorders, including mental health concerns, PCOS, and metabolic disorders.
However, it is important to use caution when evaluating such claims. While there may be some evidence that inositol might benefit certain conditions, more research is needed. Inositol should not be used as a monotherapy or in place of traditional treatments for these conditions.
Several studies have investigated the use of inositol as an add-on treatment alongsideselective serotonin reuptake inhibitors (SSRIs), which are used to treat a variety of depressive and anxiety disorders. However, results have not demonstrated an antidepressant effect.
If you are experiencing symptoms of depression or another mental health condition, talk to a doctor or mental health professional about your treatment options. Do not take inositol without talking to your doctor first, and be sure to let them know about any other medications, supplements, or substances you are currently taking to avoid drug interactions.
Depression
Inositol may have some positive effects for depression, but it is important to note that the evidence remains inconclusive. One study found that myo-inositol concentration in blood might be a reliable marker for clinical depression.
While an earlier double-blind study found that a daily 12-gram dose of inositol improved depression scores compared to people provided a placebo, the results have not been replicated elsewhere.
Panic Disorder
The compound has also been investigated for its potential impact on anxiety conditions. The benefits have mostly been seen in people with panic disorder in whom depression is common. A small study published in theJournal of Clinical Psychopharmacologyinvestigated the effect of myo-inositol on 20 people with panic disorder.
After being provided a daily 18-gram dose of myo-inositol for four weeks, the participants were given a daily 150-mg dose ofLuvox(fluvoxamine)—a commonly prescribed psychiatric drug—for the four weeks. Compared to a matched set of individuals not given myo-inositol, those who were given myo-inositol had an average of 2.4 fewer panic attacks per week.
However, more research is needed to better understand the impact inositol might have on anxiety disorders.
Bipolar Disorder
The compound has also been found to reduce psoriasis symptoms in people takinglithium, a drug commonly prescribed to treat bipolar disorder, depression, schizophrenia, andeating disorders. Depending on the usage, lithium-induced psoriasis can affect anywhere from 3% to 45% of people who take lithium.
More Research Is NeededHow inositol affects mental health conditions is not well understood and more research is needed. Some preliminary evidence indicates it may play a role in the development of depression, but research on its effects as a treatment is mixed. Some research also suggests it may have some benefits for panic disorder and bipolar disorder, but this evidence is limited and further research is needed.
More Research Is Needed
How inositol affects mental health conditions is not well understood and more research is needed. Some preliminary evidence indicates it may play a role in the development of depression, but research on its effects as a treatment is mixed. Some research also suggests it may have some benefits for panic disorder and bipolar disorder, but this evidence is limited and further research is needed.
Other Potential Health Uses for Inositol
In addition for its possible use for mental health conditions, there has been some research on inositol in the treatment of physical health conditions.
Metabolic Disorders
There is evidence to suggest inositol has benefits for metabolic disorders that contribute to the development of high blood pressure, diabetes, and metabolic syndrome. People with metabolic conditions may have a higher risk for certain mental health conditions, including depression, bipolar disorder, and schizophrenia.
A 2016 pilot study published in theInternational Journal of Endocrinologyreported that people with type 2 diabetes given myo-inositol and d-chiro-inositol daily along with their anti-diabetes drugs had a significant drop in their fasting blood glucose (192.6 mg/dL down to 160.9 mg/dL) and A1C (8.6% down to 7.7%) after three months.
Another small study published in the journalMenopausesuggested thatmyo-inositol may aid in the treatment of metabolic syndrome in postmenopausal women. According to the research, women assigned to six months of myo-inositol supplements experienced significantly greater improvements in blood pressure and cholesterol levels than women provided aplacebo.
When treated with myo-inositol, women with metabolic syndrome experienced an 11% drop in diastolic blood pressure, a 20% drop in triglycerides, and a 22% increase in “good” high-density lipoprotein (HDL) cholesterol.
All of these values translate to an improvement of metabolic syndrome as well as a decreased risk of cardiovascular disease.
Polycystic Ovary Syndrome (PCOS)
PCOS is a hormonal disorder that leads to symptoms such as menstrual irregularity, weight gain, acne, and hair loss. In addition to physical symptoms, PCOS is also associated with mental health issues, including an increased risk for anxiety, depression, and negative body image.
D-chiro-inositol may help manage PCOS, according to a small study published inEndocrine Practice. For this study, 20 women with PCOS were given either a placebo or 6 grams of D-chiro-inositol once daily for six to eight weeks.
Generally speaking, the normalization of hormonal balances translates to an improvement in PCOS symptoms.
RecapInositol shows promise in the treatment of metabolic disorders and polycystic ovary syndrome. However, further research is needed to recommend the use of inositol as a treatment. Always talk to your doctor first if you are considering taking inositol to treat a health condition.
Recap
Inositol shows promise in the treatment of metabolic disorders and polycystic ovary syndrome. However, further research is needed to recommend the use of inositol as a treatment. Always talk to your doctor first if you are considering taking inositol to treat a health condition.
Possible Side Effects of Inositol
Are there any dangers associated with taking inositol? Inositol is generally considered safe in adults. Side effects, if any, tend to be mild and may include nausea, stomach pain, tiredness, headache, and dizziness. Most side effects occur with doses greater than 12 grams per day.
The metabolic effects of inositol may not be appropriate for everyone. Even in people with diabetes, the prolonged use or overuse of inositol may lead to hypoglycemia (low blood sugar).
Although there are some studies to suggest inositol may be helpful inbipolar disease, there is also concern about it possibly causing amanic or hypomanic episode.
There is also some concern that high doses of inositol hexaphosphate may reduce the body’s ability to absorb zinc, calcium, iron, and other essential minerals, triggering nutritional deficiencies even if you’re eating a balanced diet.
As dietary supplements, inositol products are not tested for safety, and their effect on pregnant people, nursing people, and children has not been established.
Talk to a doctor before trying this or any other supplement or natural remedy. Tell your doctor about any medications, substances, or supplements you are currently taking, since inositol may cause interactions. Do not use inositol in place of proven treatments for a medical or mental health condition.
Inositol supplements are sold as tablets and capsules. There is no recommended daily allowance for inositol and there is no standardized dosing schedule.
Manufacturers recommend the following doses for supporting individual conditions:
If you decide to take an inositol supplement, speak with your doctor to ensure that it’s appropriate based on your health and medical history.
RecapWhile inositol is generally believed to be safe for adults, it may cause some side effects, particularly at higher doses. There is also a possibility of drug interactions, so always talk to a doctor before you take inositol.
While inositol is generally believed to be safe for adults, it may cause some side effects, particularly at higher doses. There is also a possibility of drug interactions, so always talk to a doctor before you take inositol.
Yes! Foods rich in inositol also offer fiber and nutrients needed for good, long-term health. These include fruits, beans, grains, and nuts. Cantaloupe, oats, bran, and citrus fruits (other than lemons) are especially rich in myo-inositol. Cooking or freezing fruits and vegetables reduces their inositol content. There is very little inositol in milk or yogurt.
The supplement is often described as a cure for thinning hair and balding, but the research is lacking. There is some evidence that inositol helps to reduce testosterone and balance hormones in people with PCOS, which may help reverse thinning hair associated with the condition.
Inositol has been shown to help improve glucose metabolism, which may help some people manage their weight more effectively. Some evidence suggests that this supplement may help women with PCOS lose weight.
While more research is needed, some preliminary studies have suggested that this compound could potentially benefit people with metabolic syndrome, diabetes, panic disorder, depression, and bipolar disorder. However, much of this research remains inconclusive. You should always talk to your doctor before taking this supplement.
18 SourcesVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Chhetri DR.Myo-inositol and its derivatives: Their emerging role in the treatment of human diseases.Front Pharmacol. 2019;10:1172. doi:10.3389/fphar.2019.01172Mukai T, Kishi T, Matsuda Y, Iwata N.A meta-analysis of inositol for depression and anxiety disorders.Hum Psychopharmacol. 2014;29(1):55-63. doi:10.1002/hup.2369Concerto C, Chiarenza C, Di Francesco A, et al.Neurobiology and applications of inositol in psychiatry: A narrative review.Curr Issues Mol Biol. 2023;45(2):1762-1778. doi:10.3390/cimb45020113Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I.Role of inositols and inositol phosphates in energy metabolism.Molecules. 2020;25(21):5079. doi:10.3390/molecules25215079Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D’Anna R.One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome.Climacteric. 2012;15(5):490-5. doi:10.3109/13697137.2011.631063Crawford TJ, Crowther CA, Alsweiler J, Brown J.Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes.Cochrane Database Syst Rev. 2015;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J.Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.Endocr Connect. 2017;6(8):647-658. doi:10.1530/EC-17-0243Chiappelli J, Rowland LM, Wijtenburg SA, et al.Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia.Neuropsychopharmacol. 2015;40(9):2157-2164. doi:10.1038/npp.2015.57Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Blemaker RH.Double-blind, controlled trial of inositol treatment of depression.Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/ajp.152.5.792Palatnik A, Frolov K, Fux M, Benjamin J.Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.J Clin Psychopharmacol. 2001 Jun;21(3):335-9. doi:10.1097/00004714-200106000-00014Wozniak J, Faraone SV, Chan J, Tarko L, Hernandez M, Davis J, Woodworth KY, Biederman J.A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: A pilot study.J Clin Psychiatry. 2015;76(11):1548-55. doi:10.4088/JCP.14m09267Penninx BWJH, Lange SMM.Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications.Dialogues Clin Neurosci. 2018;20(1):63-73. doi:10.31887/DCNS.2018.20.1/bpenninxPintaudi B, Di Vieste G, Bonomo M.The effectiveness of myo-inositol and d-chiro inositol treatment in type 2 diabetes.International Journal of Endocrinology. 2016;2016:1-5. doi:10.1155/2016/9132052Giordano D, Corrado F, Santamaria A, et al.Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study.Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1Iuorno MJ, Jakubowicz DJ, Baillargeon JP, et al.Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.Endocrine Practice. 2002;8(6):417-423. doi:10.4158/EP.8.6.417Mental Health America.Inositol.Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M.Nutritional and acquired deficiencies in inositol bioavailability. Correlations with metabolic disorders.Int J Mol Sci. 2017;18(10):2187. doi:10.3390/ijms18102187Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D.Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome.Eur J Endocrinol. 2012;166(4):703-10. doi:10.1530/EJE-11-0840
18 Sources
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Chhetri DR.Myo-inositol and its derivatives: Their emerging role in the treatment of human diseases.Front Pharmacol. 2019;10:1172. doi:10.3389/fphar.2019.01172Mukai T, Kishi T, Matsuda Y, Iwata N.A meta-analysis of inositol for depression and anxiety disorders.Hum Psychopharmacol. 2014;29(1):55-63. doi:10.1002/hup.2369Concerto C, Chiarenza C, Di Francesco A, et al.Neurobiology and applications of inositol in psychiatry: A narrative review.Curr Issues Mol Biol. 2023;45(2):1762-1778. doi:10.3390/cimb45020113Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I.Role of inositols and inositol phosphates in energy metabolism.Molecules. 2020;25(21):5079. doi:10.3390/molecules25215079Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D’Anna R.One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome.Climacteric. 2012;15(5):490-5. doi:10.3109/13697137.2011.631063Crawford TJ, Crowther CA, Alsweiler J, Brown J.Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes.Cochrane Database Syst Rev. 2015;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J.Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.Endocr Connect. 2017;6(8):647-658. doi:10.1530/EC-17-0243Chiappelli J, Rowland LM, Wijtenburg SA, et al.Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia.Neuropsychopharmacol. 2015;40(9):2157-2164. doi:10.1038/npp.2015.57Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Blemaker RH.Double-blind, controlled trial of inositol treatment of depression.Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/ajp.152.5.792Palatnik A, Frolov K, Fux M, Benjamin J.Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.J Clin Psychopharmacol. 2001 Jun;21(3):335-9. doi:10.1097/00004714-200106000-00014Wozniak J, Faraone SV, Chan J, Tarko L, Hernandez M, Davis J, Woodworth KY, Biederman J.A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: A pilot study.J Clin Psychiatry. 2015;76(11):1548-55. doi:10.4088/JCP.14m09267Penninx BWJH, Lange SMM.Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications.Dialogues Clin Neurosci. 2018;20(1):63-73. doi:10.31887/DCNS.2018.20.1/bpenninxPintaudi B, Di Vieste G, Bonomo M.The effectiveness of myo-inositol and d-chiro inositol treatment in type 2 diabetes.International Journal of Endocrinology. 2016;2016:1-5. doi:10.1155/2016/9132052Giordano D, Corrado F, Santamaria A, et al.Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study.Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1Iuorno MJ, Jakubowicz DJ, Baillargeon JP, et al.Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.Endocrine Practice. 2002;8(6):417-423. doi:10.4158/EP.8.6.417Mental Health America.Inositol.Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M.Nutritional and acquired deficiencies in inositol bioavailability. Correlations with metabolic disorders.Int J Mol Sci. 2017;18(10):2187. doi:10.3390/ijms18102187Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D.Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome.Eur J Endocrinol. 2012;166(4):703-10. doi:10.1530/EJE-11-0840
Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Chhetri DR.Myo-inositol and its derivatives: Their emerging role in the treatment of human diseases.Front Pharmacol. 2019;10:1172. doi:10.3389/fphar.2019.01172Mukai T, Kishi T, Matsuda Y, Iwata N.A meta-analysis of inositol for depression and anxiety disorders.Hum Psychopharmacol. 2014;29(1):55-63. doi:10.1002/hup.2369Concerto C, Chiarenza C, Di Francesco A, et al.Neurobiology and applications of inositol in psychiatry: A narrative review.Curr Issues Mol Biol. 2023;45(2):1762-1778. doi:10.3390/cimb45020113Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I.Role of inositols and inositol phosphates in energy metabolism.Molecules. 2020;25(21):5079. doi:10.3390/molecules25215079Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D’Anna R.One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome.Climacteric. 2012;15(5):490-5. doi:10.3109/13697137.2011.631063Crawford TJ, Crowther CA, Alsweiler J, Brown J.Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes.Cochrane Database Syst Rev. 2015;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J.Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.Endocr Connect. 2017;6(8):647-658. doi:10.1530/EC-17-0243Chiappelli J, Rowland LM, Wijtenburg SA, et al.Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia.Neuropsychopharmacol. 2015;40(9):2157-2164. doi:10.1038/npp.2015.57Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Blemaker RH.Double-blind, controlled trial of inositol treatment of depression.Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/ajp.152.5.792Palatnik A, Frolov K, Fux M, Benjamin J.Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.J Clin Psychopharmacol. 2001 Jun;21(3):335-9. doi:10.1097/00004714-200106000-00014Wozniak J, Faraone SV, Chan J, Tarko L, Hernandez M, Davis J, Woodworth KY, Biederman J.A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: A pilot study.J Clin Psychiatry. 2015;76(11):1548-55. doi:10.4088/JCP.14m09267Penninx BWJH, Lange SMM.Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications.Dialogues Clin Neurosci. 2018;20(1):63-73. doi:10.31887/DCNS.2018.20.1/bpenninxPintaudi B, Di Vieste G, Bonomo M.The effectiveness of myo-inositol and d-chiro inositol treatment in type 2 diabetes.International Journal of Endocrinology. 2016;2016:1-5. doi:10.1155/2016/9132052Giordano D, Corrado F, Santamaria A, et al.Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study.Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1Iuorno MJ, Jakubowicz DJ, Baillargeon JP, et al.Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.Endocrine Practice. 2002;8(6):417-423. doi:10.4158/EP.8.6.417Mental Health America.Inositol.Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M.Nutritional and acquired deficiencies in inositol bioavailability. Correlations with metabolic disorders.Int J Mol Sci. 2017;18(10):2187. doi:10.3390/ijms18102187Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D.Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome.Eur J Endocrinol. 2012;166(4):703-10. doi:10.1530/EJE-11-0840
Chhetri DR.Myo-inositol and its derivatives: Their emerging role in the treatment of human diseases.Front Pharmacol. 2019;10:1172. doi:10.3389/fphar.2019.01172
Mukai T, Kishi T, Matsuda Y, Iwata N.A meta-analysis of inositol for depression and anxiety disorders.Hum Psychopharmacol. 2014;29(1):55-63. doi:10.1002/hup.2369
Concerto C, Chiarenza C, Di Francesco A, et al.Neurobiology and applications of inositol in psychiatry: A narrative review.Curr Issues Mol Biol. 2023;45(2):1762-1778. doi:10.3390/cimb45020113
Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I.Role of inositols and inositol phosphates in energy metabolism.Molecules. 2020;25(21):5079. doi:10.3390/molecules25215079
Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D’Anna R.One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome.Climacteric. 2012;15(5):490-5. doi:10.3109/13697137.2011.631063
Crawford TJ, Crowther CA, Alsweiler J, Brown J.Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes.Cochrane Database Syst Rev. 2015;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2
Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J.Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.Endocr Connect. 2017;6(8):647-658. doi:10.1530/EC-17-0243
Chiappelli J, Rowland LM, Wijtenburg SA, et al.Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia.Neuropsychopharmacol. 2015;40(9):2157-2164. doi:10.1038/npp.2015.57
Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Blemaker RH.Double-blind, controlled trial of inositol treatment of depression.Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/ajp.152.5.792
Palatnik A, Frolov K, Fux M, Benjamin J.Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.J Clin Psychopharmacol. 2001 Jun;21(3):335-9. doi:10.1097/00004714-200106000-00014
Wozniak J, Faraone SV, Chan J, Tarko L, Hernandez M, Davis J, Woodworth KY, Biederman J.A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: A pilot study.J Clin Psychiatry. 2015;76(11):1548-55. doi:10.4088/JCP.14m09267
Penninx BWJH, Lange SMM.Metabolic syndrome in psychiatric patients: overview, mechanisms, and implications.Dialogues Clin Neurosci. 2018;20(1):63-73. doi:10.31887/DCNS.2018.20.1/bpenninx
Pintaudi B, Di Vieste G, Bonomo M.The effectiveness of myo-inositol and d-chiro inositol treatment in type 2 diabetes.International Journal of Endocrinology. 2016;2016:1-5. doi:10.1155/2016/9132052
Giordano D, Corrado F, Santamaria A, et al.Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study.Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1
Iuorno MJ, Jakubowicz DJ, Baillargeon JP, et al.Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.Endocrine Practice. 2002;8(6):417-423. doi:10.4158/EP.8.6.417
Mental Health America.Inositol.
Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M.Nutritional and acquired deficiencies in inositol bioavailability. Correlations with metabolic disorders.Int J Mol Sci. 2017;18(10):2187. doi:10.3390/ijms18102187
Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini D.Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome.Eur J Endocrinol. 2012;166(4):703-10. doi:10.1530/EJE-11-0840
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